Design, synthesis and biological evaluation of 7-azatricyclodecanes: analogues of cocaine

A P Tamiz; M P Smith; A P Kozikowski

doi:10.1016/s0960-894x(99)00685-x

Design, synthesis and biological evaluation of 7-azatricyclodecanes: analogues of cocaine

Bioorg Med Chem Lett. 2000 Feb 7;10(3):297-300. doi: 10.1016/s0960-894x(99)00685-x.

Authors

A P Tamiz¹, M P Smith, A P Kozikowski

Affiliation

¹ Drug Discovery Program, Institute of Cognitive and Comuputational Science, Georgetown University Medical Center, Washington, DC 20007-2197, USA.

PMID: 10698458
DOI: 10.1016/s0960-894x(99)00685-x

Abstract

The synthesis and biological activity of a series of azatricyclodecane analogues of cocaine are described. All compounds studied in this series exhibit nanomolar potency and good selectivity for the serotonin transporter versus the dopamine transporter.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Cell Line
Cocaine / chemistry*
Drug Design
Heterocyclic Compounds, 3-Ring / chemical synthesis*
Heterocyclic Compounds, 3-Ring / pharmacology*
Humans
Molecular Structure
Structure-Activity Relationship

Substances

Heterocyclic Compounds, 3-Ring
Cocaine

Grants and funding

DA10458/DA/NIDA NIH HHS/United States